Antagonists who are referred to in the very titles of the works in which they appear, whether they are protagonist villains or title antagonists. Some examples are Macbeth, Jaws, Diablo, and Carmen Sandiego.
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Akumatized villains -
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Sandboy
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Santa Claws
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Sapotis
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Satan Man
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Saul Goodman
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Sauron (Middle-earth)
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Sauron (Peter Jackson)
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Scorpion (Mortal Kombat Legends)
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Scorpion (Mortal Kombat: Defenders of the Realm)
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Sentibubbler
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Sentimonster Ladybug
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Sentimonsters
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Silencer
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Silurians
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Simon Says
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Simpleman
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Sith
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Smaug (The Hobbit)
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Sole Crusher
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Startrain
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Stoneheart
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Stormy Weather
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Style Queen
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Syren
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Taiga Nakanishi
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Tattletale Strangler
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Ted Buchanan
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The Blob (The Blob)
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The Brain
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The Bubbler
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The Collector (Miraculous: Tales of Ladybug and Cat Noir)
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The Entity (It Follows)
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The Evil Strawberry
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The Evillustrator
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The Great Khali
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The Invisible Man
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The Lorax
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The Mime
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The Pharaoh
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The Punisher Trio
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The Puppeteer
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The Spies (Spy vs. Spy)
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Timebreaker
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Timetagger
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Tomoe Tsurugi
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Troublemaker
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Truth
