The villain and antagonist with the most influence over the plot, the obstacles the protagonists face and typically the most proactive antagonist in the story; they are usually the Big Bad though they can at times be the Right-Hand or an enforcer in order to keep the Big Bad more mysterious and scary.
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A
- Absolute Titan
- Afton Robotics, LLC
- Agatha Trunchbull
- Agent Orange (Marvel Cinematic Universe)
- Airy
- Akainu
- Akihiro Kurata
- Akumu The Nightmare
- Alastor (Hazbin Hotel)
- Albert Wesker
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- Alternates
- AM
- Andrew (Fazbear Frights)
- Animatronics (Five Nights at Freddy's)
- Anti-Monitor
- Ariel Augustus
- Arnes
- Atka
- Augustus Gloop
- Azog
B
C
- Caine (John Wick)
- Camp Bullies
- Captain Blunderpants
- Carlito Keyes
- Carlton Drake (2018 Film)
- Carnage (Marvel)
- Carnage (Sony's Spider-Man Universe)
- Cartoon Cat
- Caturamon
- Cave Johnson
- Cell
- Cesare Borgia (Assassin's Creed)
- Chef (Migration)
- Chef (Trolls)
- Chris D'Amico
- Chucky
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-
- Circus Baby
-
- Cooler
- Count Dracula(Bram Stoker)
D
- Darth Maul
- Darth Vader
- Dead King Freddy
- Decepticons (Transformers Film Series)
- Denzel Crocker
-
- Dio Brando
- Doctor Doom (2000s Films)
- Doctor Eggman (Sonic Boom)
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- Donald McArthur
- Dr. Diaper
- Dr. Eggman (Archie Comics)
- Dr. Eggman (Snapcube)
- Dr. Henry Miller
- Dr. Ivo "Eggman" Robotnik
- Dr. Kulik
- Dr. Robotnik (Archie Comics)
- Dr. Robotnik (SATAM)
- Dr. Wily (Mega Man)
- Dr. Zomboss
-
E
F
G
H
J
K
L
M
- Madara Uchiha
- Major (Hellsing)
- Makuta Teridax
- Mal
- Man (Bambi)
- Mandarin
- Mangle
- Marble Henry
- Marshmallow
- Martin Greywhinder
- Mavericks
- Maxim Horvath
- Megatron (Generation One)
- Megatron (Transformers Film Series)
- Melona
- Memphis Tennessee
- Mephiles the Dark
- Michael Afton
- Midnight (Max and Midnight)
- Mira
- Miss Power