The Right-Hand is the most powerful, loyal, trusted, and authoritative henchperson of the main villain, also being the next-in-command and usually the second-to-last villain taken down by heroes.
Almost all right-hands are totally loyal to their master (even worshipping them like gods) but there are some at their side just for personal interests or feelings. While the main Villain provides a mental challenge the Right-Hand provides a physical challenge; as such it is not uncommon for a Right-Hand to be mightier than the main villain.
In some works, the Right-Hand is the The Heavy and appears more often and gets more screen time than their master, in order to make the main villain more mysterious and therefore more frightening. A main villain can also have multiple Right-Hands, either with different responsibilities or as a replacement of one who has died. Sometimes, a Right-Hand can survive their master's demise and seek to revive them or accomplish their master's goal on their behalf as in Death and Fate Averruncus's cases.
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- Scorpion (Mortal Kombat: Defenders of the Realm)
- Scorpion (Order of Darkness)
- Scourge (Transformers Reboot Films)
- Scratch and Grounder
- Scud (Toy Story)
- Sculpin
- Searchers
- Seiga Kaku
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- Shadow the Hedgehog
- Shadow the Hedgehog (Paramount Film Series)
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- Shane Walsh
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- Shang Tsung (Mortal Kombat)
- Shannon Boxman
- Shao Kahn (Mortal Kombat Annihilation)
- Shao Kahn (Mortal Kombat)
- Sharon (Poppy Playtime)
- Shion Yorigami
- Shira
- Shoichi Shinkawa
- Shurimon
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- Simon Phoenix
- Sindel (Alternate Timeline)
- Sinjin Prescott
- Sister Yulduz
- Skulker
- SkullMeramon
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- Slendrina's Child
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- Soundwave (Aligned)
- Soundwave (Generation One)
- Spice (Batman)
- Spider (Granny)
- SpongeBot SteelPants
- Spork and Spatch
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- Starscream (Transformers Film Series)
- Steve the Enderman (Wild Diamonds)
- Striker
- Stu Macher
- Sub Zero
- Sugar (Batman)
- Supreme Intelligence (Marvel Cinematic Universe)
- T-RIP
- Tabitha Galavan
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- Talon (Gotham)
- Tank (An Extremely Goofy Movie)
- Tasia
- Tatara
- Taurus (Eclipse)
- Tee Hee
- Teetsi
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- The Bensons
- The Black Widow (Marvel Cinematic Universe)
- The Corruption
- The Dark Lord
- The Delightful Children From Down The Lane
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- The Intruder (Kisterverse)
- The Rowdyruff Boys
- The Waiters (Iron Virgin Jun)
- Theo Magath
- Three Bears
- Tim (Robots)
- Tommy DeVito
- Tomoe Tsurugi
- Toralei Stripe
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- Trevor the Rat
- Trish (Devil May Cry)
- Troy and Griffin
- Twisted Freddy
- Tyene Sand