Antagonists who appear in Paramount movies, TV shows and shorts.
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- Saddam Hussein (South Park)
- Sakharine
- Satan (South Park)
- Scalpel (Transformers)
- Scar Snout
- Sentinel Prime (Transformers Film Series)
- Serena Ryan
- Shadow the Hedgehog (Paramount Film Series)
- Shelley Marsh
- Shrek (Shrek)
- Sideways (Transformers Film Series)
- SkankHunt42
- Sloan Blackburn
- Snotty Boy
- Soundwave (Transformers Film Series)
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- Squidward Tentacles
- Starscream (Transformers Film Series)
- Stromboli (Shrek)
- Swiper the Fox
T
- Tai Lung
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- Tentacular (Rumble)
- The Creators (Transformers)
- The Evil Queen (Shrek)
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- The Fallen (Transformers Film Series)
- The Frogfish
- The Goons
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- The Shredder (Live Action)
- The Thug Tug Gang
- Thimblenose Ted
- Tighten
- Tom (Tintin)
- Tortoise John
- Tour Guide
- Trees (Shrek)
- Troy and Griffin
- Tybalt (Gnomeo & Juliet)