Opportunists are self-centered antagonists/villains who place their own personal benefit above all else. They will gladly exploit any given situation to suit his or her means, commit crimes as and when it suits them do so, and break and form alliances on a whim in order to succeed.
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A
- Abaddon (Supernatural)
- Abbott Hayes
- Absolute Diavolo
- Absolute Titan
- Adam (Abraham Lincoln Vampire Hunter)
- Adam Barlow
- Admiral Rampart
- Afiko
- Afton Robotics, LLC
- Agent (Bolt)
- Agnes (Hansel & Gretel Get Baked)
- Akainu
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- Al McWhiggin
- Al-G Rhythm
- Alameda Slim
- Alejandro Burromuerto
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- Alice (Murder Drones)
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- Almighty Tallests
- Alonzo Harris
- Amanda Killman
- Andrealphus
- Andrew (Fazbear Frights)
- Aqua (Gacha League)
- Archie Mitchell
- Ariel Augustus
- Aristides Silk
- Arnes
- Art Appraiser
- Arthur (Wreck-It Ralph)
- Arthur Slugworth (Wonka)
- Asmodeus (Helluva Boss)
- ATEMS
- Audience (Danganronpa V3)
- Audrey
- August Walker
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B
- Baatar Jr.
- Baby (Resident Evil)
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- Balon Greyjoy
- Baron Corbin
- Barracuda (Marvel)
- Beautiful Gorgeous
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- Belle Fontiere
- Berkana
- Big Jack Horner
- Big Smoke
- Bill Cipher
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- Black Adam
- Black Doom
- Blaze (Mortal Kombat)
- Blitzwing (Generation One)
- Boba Fett
- Bobble the Clown
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- Bogs Diamond
- Bomb Voyage
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- Botticelli Remorso
- Bowie
- Bowser
- Bowser (The Super Mario Bros. Movie)
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- Bria
- Brock Lesnar
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- Buffalo Bill
- Burger-Beard
- Burst Man
- Butch Dog
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C
- Calvin Candie
- Calvin Fischoeder
- Camp Bullies
- Captain Phasma
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- Carla Radames
- Carmine Falcone (Nolanverse)
- Carnage (Marvel)
- Cassandra Nova (Marvel Cinematic Universe)
- Catherine Tramell
- Cell
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- Chad Charming
- Chairman Drek
- Chameleon (Mortal Kombat)
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- Chase (Total Drama)
- Chase Young
- Chef Skinner
- Chick Hicks
- Chief Goppernopper
- Christabella Gillespie
- Chucky
- Chuuya Nakahara
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- CJ Hook
- Clara (Peanuts)
- Colonel Muska
- Copperpot
- Coronel (Megaman X)
- Count Dooku
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- Crimson Knolastname
- Crooked Man (The Wolf Among Us)
- Cyrus Grissom
D
- Dag
- Daimond
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- Danny Houston
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- Dark Cetrion
- Dark Danny
- Dark Geras
- Dark Laser
- Dark Rain
- Dark Samus
- Darth Maul
- Darth Vader
- Darth Vader (Schlouden06)
- Dave Williams
- Dean Wicks
- Death Adder (Golden Axe)
- Deathborn
- Den Oonuma
- Den Watts
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- Deviot
- Diane Simmons
- Dio Brando
- Django of the Dead
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- Doctor Eggman (Sonic Boom)
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- Doll (Murder Drones)
- Dolores Umbridge
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- Doremy Sweet
- Dr. Eggman (Archie Comics)
- Dr. Eggman (Snapcube)
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- Dr. Gero
- Dr. Gregory Yates
- Dr. Ivo "Eggman" Robotnik
- Dr. Ivo Robotnik (AoStH)
- Dr. Ivo Robotnik (Paramount Film Series)
- Dr. Laura Sorkin
- Dr. Nefarious (Remake)
- Dr. Phillium Benedict
- Dr. Wily (Mega Man)
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- Dreadwing
- Drew Jacobs
- Drex (Henry Danger)
- Duke of Weselton (Frozen)
- Dushane Hill
- Dylan Gould
E
F