Antagonists who are completely obsessed with something other than power (because obsession with power counts as megalomania). Many obsessed villains are also mentally ill, though some are merely eccentric.
These type of antagonists are usually particularly obsessed with the hero themselves.
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A
- Abigail Williams (Murdered: Soul Suspect)
- Adam Grafton
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- Aerys II Targaryen
- Agatha Trunchbull
- Aggregor
- Agnes (Hansel & Gretel Get Baked)
- Ahmanet
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- Aki Sawada
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- Akira Otoishi
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- Al McWhiggin
- Al-G Rhythm
- Albert Wesker
- Allison Cowley
- Amber Canardo
- Andrew Scott
- Annie Wilkes
- Antoine Thomas
- Anton Thibodeaux
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- Ariel Augustus
- Armando and Tipa
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- Arthur Mitchell
- Asajj Ventress
- Atropos (Stephen King)
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B
- Bakerix
- Ballora
- Balthazar Bratt
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- Barty Crouch Jr.
- Belarus
- Benton Farland
- Berry
- Big Show
- Bill McLemore
- Black Hand (DC)
- Bloody Queen
- Bocarter Humphrey
- Boingo
- BoJack Horseman
- Bonnie (Bonnie's Body)
- Boogey Man
- Bowser
- Bradford Buzzard
- Brandon Breyer
- Brent ''Slappy'' Ernst
- Buffalo Bill
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- Caleb Bryant
- Calvin
- Calvin Candie
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- Carilla Pendington
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- Carlton Drake (2018 Film)
- Cat Adams
- Cat Blanc
- Cecilia Strayer
- Charles Johnson
- Charles Muntz
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- Chloe Kelcher
- Chongire
- Christine
- Cinder Fall
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- Clifford Devoe
- Colonel McCullough
- Colonel Muska
- Commodus
- Count Orlok
- Courtney (Total Drama)
- Creatures (Beastenders)
- Cupid (Arrowverse)
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D
- Da Vinci (Gakkou No Kaidan)
- Darkseid (DC Animated Universe)
- Darth Maul
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- Deathwing (Warcraft)
- Deidara
- Demongo
- Denahi
- Doctor Destiny ( DC Animated Universe)
- Doctor Robotnik (SatAM)
- Dolores Umbridge
- Don Brennan
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- Don Logan
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- Dr. Gregory Yates
- Dr. Phillip Channard
- Dr. Robotnik (2020 Film)
- Dr. Robotnik (Sonic the Hedgehog OVA)
- Dr. Ronald Meltzer
- Dr. Zara
- Draco Malfoy
- Duke of Weselton
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J
- Jackson Whittemore
- Jacques (Scooby-Doo)
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- James Savoy
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- Jason Mayberry
- Jeremy Andrus
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- Jim (Edward Scissorhands)
- Jim McDonald
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- Jivatma
- Joe Belser
- Joe Carroll
- Joffrey Baratheon
- Johan Liebert
- John Doe
- John Herbert Silverbird
- John Ryder
- Johnny Morgan
- Joker (Arkhamverse series)
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- Joker (Nolanverse)
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- Jonny 2x4