These antagonists enforce for the bigger or big bads.
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A
- Abigail Spencer
- Absolute Titan
- Adam Milligan (Ghoul)
- Admiral Rampart
- Aemon Gremm
- Afton Robotics, LLC
- Agent (Animator vs. Animation)
- Akainu
- Akumatized villains
- Akumu The Nightmare
- Alastair
- Alexandra
- Allan
- Alternates
- AM
- Amon Goeth
- Anti Spirit Team
- Aqua (Gacha League)
- Aquarius (Eclipse)
- Ares (John Wick)
- Ariel Augustus
- Aries (Eclipse)
-
Arlecchino (Genshin Impact)
- Arlong (One Piece)
- Armando and Tipa
- Armored Armadillo
- Artemisia Bell Ashcroft
- Ash Landers
- Assassin of Red (Fate/Apocrypha)
- August (Fairy Tail)
- August Walker
- Aysel
- Azog
B
- Bansai Kawakami
- Baraka
- Baron Corbin
- Bernie and Baz
-
Beverley Holiday
- Big Five
- Bin Brothers
- Black Adam
- Black Krrsantan
- Black Pegasus
- Blizzard Wolfgang
- Bloodman
- Bo-Katan Kryze
- Boba Fett
- Boiling Rock Warden
- Bomb Man
- Boss Wolf
- Bowser Jr.
- Brainbots
-
Braun Strowman
-
Breach
- Breadhead
-
Brett Wyden
- Briar
- Bridgit Pike
- Brock Lesnar
- Brutus (Peanuts)
- Butch Gilzean
-
Byro Cracy
- Byron Hadley
- Byte
C
-
Cael
- Caleb (Buffy)
- Cancer (Eclipse)
- Candy Wendy
- Captain Phasma
- Carnage (Marvel)
- CatNap
-
Cattrick Lynxley
- Caturamon
- Centipede (Deadly Venoms)
-
Cesar Jones
- Chaka (Black Lagoon)
-
Chaotic Nyala
- Chase Young
- Chozo
- Chuuya Nakahara
- Ciccio and Guido
- Cisco
- CJ Hook
- Clampdown
-
Claudia (Gacha League)
- Claws of Imperium
- Coachman's Minions
- Colonel Kaplan
-
Colonel Ritchie
- Commander Cody
-
Commander Gothmog
- Coronel (Mega Man X)
- Creator Luni
- Crimson Dawn
- Crystal Man
D
-
D'Vorah (Mortal Kombat Legends)
-
D'Vorah (Mortal Kombat)
- Daegon
- Dai Li
- Dalton McCann
-
Daniel Bryan
- Dark Dragon (Fairy Tail)
- Dark Geras
- Darrius
- Darth Vader
- Darth Vader (Angry Birds Star Wars)
- David Smith
- Deacon Frost (Blade)
- Death Troopers
- Demongo
- Dieter Klein
- Dieter Stark
- Dimaria Yesta
-
Disassembly Drones
- Dolores Umbridge
- Don Crustyoni's Bodyguards
- Donnie Bidwell
- Doug Ramses
- Dr. Doppler
- Dr. Eggman (Archie Comics)
-
Dr. Gacha
- Dr. Ivo "Eggman" Robotnik
- Dr. Kulik
- Dr. Phillip Channard
- Dr. Poison (DC Extended Universe)
- Dr. Robotnik (Archie Comics)
- Dr. Royce Hemlock
-
Dr. Silver
- Drake Merwin
- Dreadpool
- Dreadwing
- Drew McIntyre
E
- Earth Empire
- Eberwolf
- Eddie Pulaski
- El Pollito (Despicable Me)
-
Elaine
- Elder Toguro
- Emperor (Akame Ga Kill!)
- Erik and Francis
- Ermac (Mortal Kombat Annihilation)
- Ermac (Mortal Kombat)
- Ermac (Order of Darkness)
- Erron Black
- Esdeath
- Eska and Desna
- Eto Yoshimura
- Evelyn Claythorne
- Evil Executioner
-
Evil Flippy
- Exorcists
F
G
- Gahri
- Galactic Empire
- Ganbo
-
Gaston's Buddies
- Gekomon
- General Cryptor
- General Kalani
- General Kozu
- General Otmin
- General Shao
-
Geras
-
Ghostly Blanket
- Gia DeLuca
- Gil
-
Gina Glitch
- Gmork
- Go-Jaraji-Da
- God Serena
- Goenitz
- Gold Toothed Doctor
- Goosey Loosey
- Goro (Mortal Kombat)
- Goumon
- Greed (Fma Manga & Brotherhood)
- Gregory Goyle
- Grem and Acer
- Griffon (Devil May Cry)
- Ground Scaravich
- Gunther (WWE)