The antagonist who is the one causing all of the problems of the story. Generally the primary antagonist, though not always. This antagonist will usually be at the center of the plotline, or either working behind the scenes.
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Gus Fring -
Holli Would -
Red John -
Major (Hellsing) -
Erebus -
Scoutmaster Lumpus -
Junko Enoshima -
Light Yagami
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A
B
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- Bartholomew Roberts (Assassin’s Creed)
- Bernkastel
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- Bill Cipher
- Bill Sikes
- Black Cuervo
- Blair Witch
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- Bocarter Humphrey
- Bonnie
- Bowser
- Bowser Jr.
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- Bradford Buzzard
- Brainiac
- Brainiac (DC Animated Universe)
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- Brokenstar
- Brown Sharptooth
- Burton Jernigan
C
- Cad Bane
- Cameron Campbell
- Captain Chantel DuBois
- Captain Cold
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- Cat R. Waul
- Cell
- Cersei Lannister
- Cesare Borgia (Assassin's Creed)
- Chairman Drek
- Charles Muntz
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- Chef
- Chernabog
- Cinder Fall
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- Claudia & Klaus Furschtein
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- Clone trooper
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- Commander Black (Showa Era)
- Commander Cody
- Commander Karbin
- Commodus
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- Count Dooku
- Count Dracula(Bram Stoker)
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- Courtney (Total Drama)
D
- D-Reaper
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- Damian Cooper
- Darkseid (Comics)
- Darkseid (DC Animated Universe)
- Darla Dimple
- Darren Lattimer
- Death (Final Destination)
- Demon King (Nanatsu no Taizai)
- Director Kakuzawa
- Doctor Eggman
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- Dr Evil
- Dr. Alexander Isaacs
- Dr. Babylon
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- Dr. Muraki Kazutaka
- Dr. Nefarious
- Dr. Robotnik (Sonic the Hedgehog OVA)
- Dr. Wily
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- Drayton Sawyer
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- Dwight Pollard (Gotham Rebelverse)
E
F
G
- Galactus
- Galvatron (Generation One)
- Gargos
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- General Aldo
- General Grievous
- General Mandible
- General Modula
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- General Ursus
- Geoffrey (Fairy Tail)
- Ghostface
- Ginormous
- Gladys Pain
- Goenitz
- Goku Black
- Gonzo Tarukane
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- Gorilla Grodd
- Gorrath
- Grand High Witch
- Green Goblin
- Green Goblin (Sam Raimi trilogy/Spider-Man: No Way Home)
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- Gus Fring
H
J