Archenemy

“	I know every move of your game. You can do nothing before Monday. It has been a duel between you and me, Mr Holmes. You hope to place me in the dock. I tell you that I will never stand in the dock. You hope to beat me. I tell you that you will never beat me. If you are clever enough to bring destruction upon me, rest assured that I shall do as much to you.	„
	~ Professor Moriarty's famous speech to Sherlock Holmes in 'The Final Problem' - indicating the inevitable final confrontation between the master criminal and the consulting detective.

“	In a comic, you know how you can tell who the arch-villain's going to be? He's the exact opposite of the hero.	„
	~ Elijah Price explaining his connection to David Dunn.

An Archenemy is the main enemy of the protagonist. The reason why the particular villain stands out more than the rest varies; they may be the hero's strongest enemy, be the complete antithesis to the hero, have strong connections with their hero's past, pose the greatest threat, or may be the most recurring villain. Examples of Archenemies: The Joker from the Batman comics, Lex Luthor from the Superman comics, Agent Smith from The Matrix trilogy, The Leader from The Hulk comics, Ghostface from the Scream series, Jafar from Aladdin, Bowser from the Mario series, Dr. Eggman from the Sonic the Hedgehog series, Nigel from Rio, and Sephiroth from Final Fantasy VII and Revolver Ocelot from the Metal Gear Solid series, The Killer/William Afton/Springtrap from the Five Nights at Freddy's series. They are also Big Bads if they are the people responsible for everything. For an anime/manga example, Frieza for Goku, Cell for Gohan, and Majin Buu for Supreme Kai from Dragon Ball.