Kanker Sisters

The Kanker Sisters are the main antagonists of the Ed, Edd n Eddy series and later anti-heroes of the series finale movie Ed, Edd n Eddy's Big Picture Show. They are a trio of sisters who live in the trailer park in the outer portions of Peach Creek are the most infamous inhabitants of the cul-de-sac. They strike fear into the hearts of all the kids and are the fears of the Eds, the latter of which they have huge crushes on and constantly seek after whenever they appear in an episode.

Personalities
Each of the Kankers have a crush on the Eds (blonde May being into Ed, blue-haired Marie being into Edd / Double D, and redhead Lee being into Eddy) and are the cruel, merciless, sadistic, and unkind bullies of Peach Creek, attacking everyone in the cul-de-sac to no end.

The origins of the Kankers are convoluted. While they are definitively sisters and all live together, they appear to have three different fathers but only one mother. This seems to suggest that they are actually half-sisters, sharing a mother but each having a different father, which would explain the lack of physical resemblance between them and live in a trailer.