Yokoth

Yokoth is a lovecraftian goddess from another universe, she also served as the main antagonist of the episode The Thing of Supernatural.

Supernatural
Yokoth is an interdimensional goddess who is the mother of the faceless Horde, and companion of Glythur. One day when one of the rogue Men of Letters, then psychotic Diego Avila in 1925, he decided to free Yokoth and Glythur to punish humans. However only Yokoth managed to break free in the body of a woman named Sandy Porter who was women the Men of Letters had kidnapped to perform the ritua. With that she killed everyone who was there, and the surviving Men of Letters locked her in the house. Until the arrival of the Winchesters. She then manipulated the Winchesters, and the descendents kidnapped Sam and reveal the truth about Yokoth. Shortly after Yokoth captures Dean, and reveals himself with such, she also claims that she was attracted to Dean and would use his body for Glythur to pass. However the plan is frustrated when the descendants and Sam appear, Dean seizes the opportunity and casts Yokoth's cord to Ophelia as she does the reversal spell leaving Yokoth desperate then, Glythur takes Yokoth with him.