Lous Griffin

Lois Patrice Pewterschmidt-Griffin (born February 18, 1956) is the deuteragonist in the FOX animated TV series, Family Guy. Originally she was a protagonist, but as she became darker, despite being one of the protagonists, she does have several episodes where she has an antagonistic role.She is voiced by Alex Borstein, who is well-known for her portrayal of Ms. Bonnie Swann on the hit satirical comedy show MADtv.