Mr. Freeze

Mr. Freeze is an antagonist in DC Animated Universe who was once a scientist trying to cure his wife but was shut down by corrupt businessman. He later got into an accident that made him unable to live outside of a sub zero environment. This incarnation of Mr. Freeze singlehandedly retconned his personality from a cookie cutter mad scientist to a deeply tragic villain. He was voiced by the late Michael Ansara.

Heart of Ice
Victor Fries was once a stoic scientist who didn't really feel any happiness until he met Nora who later became his wife. Nora later became infected with a terminal illness that was rare so Victor used equipment from Gothcorp, the company he works for. However, Ferris Boyle the CEO shuts it down since Victor didn't have his authorization. He was later kicked into a table filled with unknown chemical by Boyle and left for dead.

Victor became unable to survive in warm temperatures and dons a suit that met his temperature needs and call himself Mr. Freeze. He recruits a group of henchmen to avenge his wife by destroying Gothcorp property and eventually tries to kill Boyle. However, Batman foiled that attempt and Freeze was sent to Arkham while Boyle gets arrested.